Cao P, Jiang L, Zhou LY, et al. - In gallbladder carcinoma (GBC) cases, preoperative serum fibrinogen levels and platelet counts might serve as dependable biomarkers for the occurrence of disease, tumor depth, lymph node metastasis, distant metastasis and advanced Tumor Node Metastasis (TNM) stage.

• This study involved 58 patients with GBC, 60 patients with cholesterol polyps and 60 healthy volunteers.

• Preoperative fasting serum fibrinogen levels and platelet counts were recorded.

• Relative to healthy gallbladder and cholesterol polyp of gallbladder, GBC patients had significantly higher levels of fibrinogen.

• Fibrinogen levels in GBC patients were related to tumor depth (p = 0.001), lymph node metastasis (p = 0.002), distant metastasis (p < 0.001) and TNM stage (p < 0.001).

• The low fibrinogen level group had better overall survival relative to high fibrinogen level group.

• Serum fibrinogen levels might represent a prognostic factor to predict outcome for GBC patients suffering from surgery treatment.

• In future explorations, consideration might be given to anticoagulation therapy to control cancer progression.