Meun C, Gunning MN, YV, et al. - Researchers conducted a cross-sectional study to evaluate the cardiometabolic phenotype and prevalence of cardiovascular disease (CVD) in middle-aged women (n = 200; aged > 45 years; mean age: 50.5 years) with polycystic ovary syndrome (PCOS) compared with age-matched controls (n = 200; mean age: 51.0 years) from the general population. They also estimated 10-year CVD risk and cardiovascular health scores. Increased waist circumference, BMI, and hypertension in women with PCOS were more commonly reported than among controls. Among women with PCOS, there was no significant increase in the prevalence of type 2 diabetes or metabolic syndrome and no variation in lipid levels from controls. In women with PCOS, carotid intima media thickness was lower. In women with PCOS and controls, calculated cardiovascular health and 10-year CVD risk were similar. Middle-aged women with PCOS were shown to have only a moderately unfavorable cardiometabolic profile vs age-matched controls, although they have increased BMI and waist circumference values. In addition, there was no evidence to support increased (10-year) CVD risk or more severe atherosclerosis vs controls from the general population. Long-term follow-up of women with PCOS is, however, required to provide a conclusive answer to long-term CVD risk.