Yip CSC, et al. - Researchers summarized the associations of fruit and vegetable intakes with global burden of diseases reported in published meta-analyses, and reported on the best relative risk estimates. For each 100-g/day increase in fruit intakes, the highest identified linear dose responses were 0.56 for esophageal cancer and 0.72 for mouth, pharynx, and larynx cancer. For the first 100 g/day of fruit intake, the identified nonlinear dose responses were 0.86 for stroke and 0.89 for all-cause mortality. For each 100-g/day increase in vegetable intake, the highest identified linear dose responses were 0.88 for renal cell cancer and 0.89 for non-Hodgkin lymphoma; nonlinear dose responses for the first 100 g/day of vegetable intake were 0.86 for coronary heart disease, followed by 0.87 for all-cause mortality. The investigators also noted positive associations of canned fruit intake with all-cause and cardiovascular disease mortality; pickled vegetable intake was positively associated with stomach cancer as well. Overall, existing recommendations for fruit and vegetable intakes were supported.