Fu SC, et al. - Through a meta-analysis based on the evidence currently available from the literature, the researchers intended to make a more precise judgment of the connections of tumor necrosis factor-α (TNF-α) gene polymorphisms with bone mineral density (BMD) and risk of osteoporosis. For eligible studies, the PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure, and Wan Fang databases were explored. A total of 15 studies comprising 5,273 citizens were involved. Under a mutant model, the GG genotype of TNF-α G308A was observed to be affiliated with an elevated risk of osteoporosis. A meaningful correlation among G308A polymorphism and BMD of the lumbar spine was also discovered. Although, no obvious influences of TNF-α T1031C, C857T and, C863A polymorphisms on osteoporosis risk could be ascertained. Hence, for screening, diagnosis, and treatment of osteoporosis, TNF-α G308A polymorphism could act as a potential candidate biomarker, which could assist in improving individualized therapy of osteoporosis victims in clinics.