Kerr CJ, Waterworth SP, Brodie D, et al. - The lowest prevalence of non-alcoholic fatty liver disease was found in adults achieving >60 min per week of vigorous physical activity. Nevertheless, there was a stronger dose-response association between cardiorespiratory fitness and non-alcoholic fatty liver disease. There is a need for future study for improving cardiorespiratory fitness as a potential therapeutic target for the treatment and prevention of non-alcoholic fatty liver disease.

• In our sample of 7,111 adults, non-alcoholic fatty liver disease prevalence was 28.3% in males, and 6.5% in females.

• Furthermore, logistic regression demonstrated the relative odds of non-alcoholic fatty liver disease were 42% lower whether >60 min per week of vigorous physical activity was maintained (OR=0.58 CI: 0.49-0.68).

• A negative dose-response relationship was found between cardiorespiratory fitness and non-alcoholic fatty liver disease between Q1-Q4.

• Odds were 39% (OR=0.61, CI: 0.51-0.73) lower in Q2, through to 51% lower in Q5 (OR=0.49, CI: 0.41-0.60) in comparison with Q1.

• The odds of non-alcoholic liver disease were not reduced by moderate physical activity.