Shardlow A, McIntyre NJ, Kolhe NV, et al. - This prospective analysis was designed to determine whether skin autofluorescence (SAF) is a risk factor for cardiovascular events (CVEs) and all-cause mortality (ACM) in patients suffering from chronic kidney disease (CKD) stage 3. From 32 primary care practices across Derbyshire, United Kingdom, individuals with estimated glomerular filtration rate (eGFR) 59 to 30 mL/min/1.73 m² on two consecutive previous blood tests were recruited between 2008 and 2010. At baseline, 1, and 5 years, SAF was recorded in patients with CKD stage 3. Findings demonstrated SAF as an independent risk factor for CVE as well as ACM in patients with early CKD. Based on the observations, it was inferred that cardiovascular risk in CKD may be attenuated by implementing interventions to decrease AGE (advanced glycation end product) accumulation, such as dietary AGE restriction, however, this needs testing in prospective randomised trials. Experts doubt the applicability of the findings in more ethnically diverse or younger groups.