The association of polymorphisms in TNF and ankylosing spondylitis in common population: A meta-analysis
European Spine Journal Apr 25, 2021
Hu N, Chen X, Wang S, et al. - This study was sought to conduct a meta-analysis based on the evidence available from the literature up-to-date to further clarify this relationship. Researchers carried out to search the PubMed, Embase, and Cochrane databases (up to March 2020). They used pooled and individual odds ratios with 95% confidence intervals of the minor allele of each locus to evaluate the relationships between TNF polymorphisms and ankylosing spondylitis in different ethnicities in a common population. This meta-analysis enrolled 17 studies, consisting of seven European studies, eight East Asian studies, and two Latin-American studies, were included. The meta-analysis implies that TNF-α polymorphisms at positions − 238, − 308, − 850, − 1031, and rs769178 could have an influence on ankylosing spondylitis susceptibility in the total population. No association was found between TNF-376, TNF-857, TNF-863 polymorphisms, and ankylosing spondylitis. In the subgroups, some results are not consistent with those in the total population.
-
Exclusive Write-ups & Webinars by KOLs
-
Daily Quiz by specialty
-
Paid Market Research Surveys
-
Case discussions, News & Journals' summaries