Fani L, van der Willik KD, Bos D, et al. - Among participants of the population-based Rotterdam Study without atherosclerotic cardiovascular disease (ASCVD) at baseline, researchers examined the link of components of innate and adaptive immunity longitudinally with ASCVD, and evaluated if arterial calcifications play a role in this link. The participants were assessed for granulocyte (innate immunity) and lymphocyte (adaptive immunity) counts and were observed until 1 January, 2015. There were 7,730 participants (59.4% women) in total, among those, ASCVD occurred in 801, as noted during a median follow-up of 8.1 years. A higher risk of ASCVD was observed in the general population in relation to an increased granulocyte count. A link was also evident between higher levels of granulocytes and larger volumes of arterial calcification. It was suggested that a proportion of the association between granulocytes and ASCVD may be explained by arterial calcifications.