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The association of delta neutrophil index with the prognosis of acute exacerbation of chronic obstructive pulmonary disease

BMC Pulmonary Medicine Feb 27, 2020

Park S, Lee SJ, Shin B, et al. - Given increased delta neutrophil index (DNI) can be beneficial in the identification of COPD patients with pneumonia, researchers assessed the mortality rate of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) patients with or without community-acquired pneumonia who got readmitted within 6 months following discharge from the hospital. They also evaluated the cumulative survival rate based on serum DNI level and readmission duration of AECOPD patients. In multivariate analysis, it was shown that readmission duration ≤ 30 days; and serum DNI level were significantly related to the mortality of AECOPD patients during 6 months. An area under the curve of 0.753 was generated for readmission (≤ 30 days) + DNI level (≥ 3.5%), with a sensitivity and specificity of 73.7% and 67.3%, respectively. Findings revealed higher mortality for AECOPD patients who were readmitted ≤ 30 days and DNI ≥ 3.5%. In AECOPD patients who get readmitted post-discharge, the prognosis can be predicted by evaluating the DNI level.
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