Shi YY, Zheng R, Cai JJ, et al. - This analysis was carried out to investigate if a higher triglyceride glucose (TyG) index is correlated with a higher odds of depression. Between 2005 and 2018, researchers conducted an observational study using data from the National Health and Nutrition Examination Survey, a cross-sectional and nationally representative database. The Patient Health Questionnaire-9 was used to evaluate depression. They calculated the TyG index based on the equation as follows: ln [triglyceride (mg/dL) × fasting blood glucose (mg/dL)/2], and participants were divided into quartiles based on the TyG index. The relationship between the TyG index and depression was investigated by using weighted multivariable logistic regression models. The study population consisted of 13,350 patients, involving 1001 (7.50%) individuals with depression. This large cross-sectional study implies that populations with higher TyG index are significantly more likely to have depressive symptoms in U.S. adults.