Skiba MB, Kohler LN, Crane TE, et al. - Among postmenopausal women, researchers examined the link between prebiotic use and colorectal cancer risk and mortality in the Women's Health Initiative study. At study enrollment, self-reported prebiotic use was determined. Medical and death records were used to capture adjudicated colorectal cancer cases and mortality. They estimated the HR associated with prebiotic use and colorectal cancer risk and mortality, using Cox proportional hazards models. An average 15.4 years of follow-up was performed, during which, 3,032 colorectal cancer cases were diagnosed. The use of a prebiotic with psyllium was reported in 3.7% of women. Findings revealed no link between prebiotic fiber supplement use and colorectal cancer risk. Higher colorectal cancer mortality was observed in relation to insoluble, but not soluble, prebiotic fiber use. Based on these findings, the promotion of prebiotic fiber supplements to decrease colorectal cancer risk or colorectal cancer mortality was not supported.