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The association between P selectin glycoprotein ligand 1 gene variable number of tandem repeats polymorphism and risk of thrombosis in Behçet's disease

International Journal of Rheumatic Diseases Feb 01, 2019

Cosan F, et al. - Given that Behçet's disease (BD) has been recognized as an unclassified type of vasculitis with an accompanying tendency to thrombosis, researchers examined the association of P-selectin glycoprotein ligand-1 (PSGL-1) gene polymorphism, in a group of BD patients with and without thrombosis. Compared to BD patients without thrombosis, the frequency of heterozygous genotypes was greater in BD patients with thrombosis. However, the increased frequency of heterozygous genotypes has not reached a statistically significant level in BD patients with thrombosis compared to healthy controls. In patients with BD, PSGL-1 variable number of tandem repeat (VNTR) polymorphism might have limited contribution to the thrombotic tendency.
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