Cosan F, et al. – In this current study, the physicians evaluated the association of P–selectin glycoprotein ligand–1 (PSGL–1) gene polymorphism, in Behçet's disease (BD) patients with and without thrombosis. Their investigations indicated that PSGL–1 VNTR polymorphism might have limited contribution to the thrombotic tendency in patients with BD.

Methods

• This study included 136 BD patients (112 male, 24 female) with thrombosis, 120 BD patients without thrombosis (54 male, 66 female) during at least 5 years disease course, and 190 healthy controls (103 male, 87 female).
• All patients fulfilled the International Study Group criteria for classification of BD. 
• Genotyping for the PSGL–1 gene exon 2 VNTR polymorphism was carried out with the amplification of genomic DNA and running of the polymerase chain reaction product on agarose gel electrophoresis.

Results

• In BD patients with thrombosis, the frequency of heterozygous genotypes (AB+AC+BC) was greater compared to BD patients without thrombosis (33.1%vs. 20.8%, P = 0.028, odds ratio = 1.85).
• However, the increased frequency of heterozygous genotypes in BD patients with thrombosis did not reach a statistically significant level compared to healthy controls (33.1% vs. 32.6%).