Kuchibhatla M, Hunter JC, Plassman BL, et al. - Given that a limited but growing body of evidence supports a link between neighborhood socioeconomic status (NSES) and cognitive decline, researchers sought to define this association controlling for risk factors like cardiovascular, cerebrovascular, and genetic risk factors. Cognitive decline was evaluated in connection with NSES, and cardiovascular and cerebrovascular risk factors (heart disease, diabetes, hypertension, and stroke) in 8,198 people from the 1992–2010 waves of the Health and Retirement Study (HRS). The HRS sample was 57.6% female and 85.5% White, with a baseline mean age of 67.5(3.5) years. The three-quadratic-class model best suits the data where the better cognitive function was expressed by higher classes. People with better cognitive function were mostly younger white females. It was noted that those in the highest quartile of NSES had 57% higher chances of being in the high cognitive function class. Heart disease, diabetes, hypertension, and stroke each raised the chances of lower cognitive function. In analyzing the cognitive status relationship with different factors, neighborhood socioeconomic status, cardiovascular risk, and cerebrovascular risk continued across the cognitive trajectory classes.