Banning LCP, Ramakers IHGB, Köhler S, et al. - Researchers examined how Alzheimer disease biomarkers are associated with neuropsychiatric symptoms. Two large cohort studies, the Dutch Parelsnoer Institute – Neurodegenerative Diseases and the Alzheimer's Disease Neuroimaging Initiative provided data of individuals with subjective cognitive decline (N = 650), mild cognitive impairment (N = 887) and Alzheimer's disease dementia (N = 626) for this analysis. Outcomes suggest no correlation of Alzheimer disease biomarkers with depression, agitation, irritability, and sleep disturbances. The presence of anxiety was reported in correlation to exhibiting lower levels of CSF Aβ₄₂, higher levels of t- and p-tau. The presence of apathy was reported in correlation to exhibiting lower levels of CSF Aβ₄₂ and smaller hippocampal volumes. Cognitive functioning mediated all associations.