Xu J, et al. - Among prospectively recruited patients receiving total knee arthroplasty (TKA), researchers focused on the link of preoperative anxiety, depression, and locus of control (LoC), with patient outcomes post-TKA. This study included 136 patients. They found correlations of greater preoperative depression and anxiety scores with worse total Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score at 6 weeks and 18 weeks after surgery, respectively. Also, they identified a correlation of poorer pre-operative SF-12 mental score with a worse total WOMAC score at 6 weeks after the operation. Correlation between a greater tendency towards an internal LoC preoperatively and better WOMAC pain and function scores at 18 weeks after surgery was observed. In this study, a group of patients was recognized as having psychosocial markers predicting worse outcomes in short to medium term in these patients despite normalization to satisfactory outcomes at 1-year after the surgery. Targeted intervention with an adjustment of expectations and more effective recovery could be enabled as a result of the detection of this group.