Wang G, Ouyang J, Li S, et al. - Researchers gathered and investigated human diabetic nephropathy (DN) prognostic markers (independent risk factors for DN progression) in order to catch the key pathways and molecules that actually impact DN progression from various published studies. Numerous pathways were significantly enriched analogous to various endpoint events. The TNF signaling pathway played a role via the process of DN progression and adipocytokine signaling pathway was uniquely enhanced in end-stage renal disease. Molecules, such as TNF, IL6, SOD2, etc, were very significant for DN progression, among which, it seems that “AGER” played a crucial role in the mechanism. A database, DataBase for Prognostic markers of Kidney Diseases, was constructed comprising all the gathered prognostic markers. Hence, a database for all prognostic markers of five prevalent chronic kidney diseases, offering some bioinformatics analyses of DN prognostic markers and providing beneficial insights towards learning the fundamental mechanism of human DN progression and for recognizing new therapeutic targets was made.