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Ten-year survival outcomes of patients with potentially resectable gastric cancer: Impact of clinicopathologic and treatment-related risk factors

Annals of Gastroenterology Feb 12, 2019

Koumarianou A, et al. - Between 2006 and 2010, researchers statistically analyzed the clinicopathologic characteristics, treatments and outcomes of patients with potentially resectable gastric cancer (GC), the fifth most frequent cancer and the third cause of cancer-related deaths worldwide, managed at Attikon University General Hospital. The STROBE checklist was applied in this retrospective cohort study. According to findings, gastrectomy with lymphadenectomy D1 or D2 significantly improves the survival of GC patients and is the optimal surgery for resectable GC patients. The worst negative prognostic factors for survival were microscopic and macroscopic infiltration of surgical margins. It is of the utmost importance to achieve R0 (no cancer cells identified microscopically at the circular or linear, proximal or distal resection margin) surgical resection. These outcomes are equivalent to those of centers of excellence and show the urgent need for improvement in the field, especially in the development of predictive models for personalized treatment.
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