Vantyghem MC, Chetboun M, Gmyr V, et al. - In patients with type 1 diabetes (T1D) and hypoglycemia unawareness and/or a functioning kidney graft, researchers assessed the 10-year outcome of islet transplantation. The study sample consisted of 28 individuals with T1D who received islet transplantation either alone (ITA) or after a kidney graft. Evaluated 1 month after the last islet infusion, primary graft function was significantly linked to the duration of graft function and insulin independence. The results obtained from this prospective parallel-arm cohort study indicate that in three-quarters of patients with T1D, kidney transplanted or not, islet transplantation with the Edmonton protocol can provide 10-year markedly improved metabolic control without severe hypoglycemic events.