Digma LA, et al. - Researchers explored the connection between cross-sectional measures of tau, cortical thickness, and different aspects of cognition using multi-modal imaging and neuropsychological battery data available in the Alzheimer Disease Neuroimaging Initiative. Data were analyzed from 131 amyloid-β positive candidates [average age was 77.8 (±7.3) years] of the Alzheimer Disease Neuroimaging Initiative who underwent MRI, flortaucipir positron emission tomography, and neuropsychological testing. The results show that the decline in domain-specific cognitive performance linked to Alzheimer disease reflects the underlying progression of tau and atrophy into associated brain circuits. In addition, compared with MRI-derived measures of cortical thickness, tau-PET may have better sensitivity to this decline.