Lascarrou JB, Merdji H, Le Gouge A, et al. - Through an open-label, randomized, controlled trial researchers contrasted moderate therapeutic hypothermia (33°C during the first 24 hours) with targeted normothermia (37°C) in individuals with coma who were admitted to the ICU following resuscitation from cardiac arrest with nonshockable rhythm. A total of 584 patients from 25 ICUs were randomized, and 581 were involved in the analysis (three patients withdrew consent). On day 90, with a Cerebral Performance Category score of 1 or 2, a total of 29 of 284 individuals in the hypothermia group, in comparison with 17 of 297 in the normothermia group, were alive. Between the hypothermia group and the normothermia group, mortality at 90 days did not vary markedly. The incidence of prespecified adverse events did not vary considerably among groups. Therefore, moderate therapeutic hypothermia at 33°C for 24 hours resulted in a greater percentage of individuals who endured with a favorable neurologic outcome at day 90 in comparison with the one seen with targeted normothermia among individuals with a coma who had been resuscitated from cardiac arrest with nonshockable rhythm.