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Targeted temperature management at 33 vs 36 degrees: A retrospective cohort study

Critical Care Medicine Feb 24, 2020

Johnson NJ, Danielson KR, Counts CR, et al. - Researchers undertook this retrospective, before-and-after, cohort study, to examine the link between targeted temperature management goal temperature of 33°C vs 36°C and neurologic outcome following out-of-hospital cardiac arrest. This inquiry was performed at an urban, academic, level 1 trauma center from 2010 to 2017. Participants were adults who encountered nontraumatic out-of-hospital cardiac arrest and received targeted temperature management. Older age and more arrests of cardiac etiology were reported in patients treated during targeted temperature management 33°C, but otherwise these patients exhibited similar baseline features, including initial cardiac rhythm. Findings revealed higher odds of neurologically intact survival to hospital discharge among comatose, adult out-of-hospital cardiac arrest patients treated during the targeted temperature management 33°C period vs those treated during the targeted temperature management 36°C period. Experts identified no significant difference in hospital mortality.
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