Hara C, Wakabayashi T, Fukushima Y, et al. - Researchers undertook this retrospective, interventional, consecutive case series, to determine the features of patients who contracted tachyphylaxis on repeated intravitreal aflibercept (IVA) injections for neovascular age-related macular degeneration (AMD) as well as the frequency of tachyphylaxis. This study included 313 eyes (313 patients) with treatment-naïve AMD with resolution attained soon following the initiation of IVA and observed for ≥ 12 months. They examined the eyes for tachyphylaxis to aflibercept. Findings revealed that a minority of patients with AMD developed tachyphylaxis after repeated IVA injections for the long term, and the possibility of its occurrence was more in eyes with lesions beneath the retinal pigment epithelium and no intraretinal edema. Treatment of AMD should be conducted considering this fact while taking into account the consecutive treatment.