Bowen AJ, et al. - Researchers sought to capture the experience of a large cohort of patients with unexplained chronic cough (UCC) over an extended period, looking for tachyphylaxis or dependence to neuromodulators over time. They defined tachyphylaxis as the need for higher doses of medication after diminishing therapeutic benefit, while they defined dependence as a failure to stop therapy after attempted de-escalation or resurgence following drug cessation. During UCC treatment, tachyphylaxis and dependence occur frequently and effects the treatment outcomes majorly. Sometimes distinct responses to different neuromodulator classes were demonstrated by patients. Successful treatment for cough would be experienced by the majority of patients.