Garudadri S, et al. - Researchers analyzed the data to assess the association of symptoms, exacerbations, and functional dimensions of disease severity among smokers with preserved spirometry with markers of systemic inflammation. They noticed a correlation between C-reactive protein (CRP) and inclined symptom burden with a greater number of exacerbations in the year before study enrollment. They also found that soluble tumor necrosis factor [TNF] receptors [sTNFRSF1A] was correlated with symptom burden on the basis of the COPD assessment test score. A negative relationship between CRP, sTNFRSF1A levels and 6-minute walk distance was recorded but not with IgE and eosinophils.