Systematic review and meta-analysis of gender specific differences in adverse events after open and endovascular intact abdominal aortic aneurysm repair: Consistently worse outcomes for women
European Journal of Vascular and Endovascular Surgery Aug 04, 2021
Pouncey AL, David M, Morris RI, et al. - Following the repair of an abdominal aortic aneurysm, women are still at an increased risk of death. After endovascular aneurysm repair (EVAR) and open aneurysm repair (OAR), women had a greater rate of transfusion, pulmonary, and gastrointestinal problems.
Participants in the study were 371,215 men and 65,465 women.
According to meta-analysis and meta-regression, the gender-specific odds ratios for 30-day mortality remained unchanged from 2000 to 2020.
Women had a higher mortality risk for OAR and an even higher risk for EVAR, and this remained after multivariable risk adjustment.
Following EVAR, women were more likely to experience arterial injury, limb ischaemia, renal, and cardiac problems, the latter of which was linked to higher mortality risk in meta-regression.
Higher mortality risk ratios for EVAR may be caused by cardiac complications, additional arterial injury, and embolisation, which can result in renal and limb ischaemia.
Such findings point to potential causes of observed outcome disparities as well as areas for quality improvement.
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