Bongiovanni T, Lancaster E, Ledesma Y, et al. - Researchers aimed at understanding the perioperative bleeding risk caused by NSAIDs (nonsteroidal anti-inflammatory drugs), which have been touted as an adjunct, or even replacement, for opioids. A search of electronic databases (MEDLINE, EMBASE) was performed by a physician–librarian team, using search terms covering the targeted intervention (use of NSAIDs) and outcomes of interest (surgical complications, bleeding). Screening of a total of 2,521 articles was done, and selected were 229 articles for detailed assessment. Seventy-four manuscripts met inclusion criteria spanning years 1987–2019 including reference searching. A total of 151,031 patients were included in these studies. Among the 12 types of NSAIDs included in the studies, the most common were ketorolac, diclofenac, and ibuprofen, over a wide–range of procedures, from otorhinolaryngology (ENT), breast, abdomen, plastics, and more. Findings suggest no increased tendency for postoperative bleeding complications in correlation with providing NSAIDs. A large number of patients has been covered in this literature and consistency remains across types of NSAIDs and operations.