Bannon CA, Gallacher D, Hanson P, et al. - Researchers conducted the study for comparing metabolic effects of Modified‐Release Hydrocortisone (MR‐HC) with Standard Glucocorticoid (SG) replacement in adults with adrenal insufficiency (AI). They searched PubMed/Medline, EMBASE, CINAHL, and CENTRAL to identify relevant articles, published before August 2019. Meta‐analysis from RCTs (n = 2), 104 patients have been switched from SG to MR‐HC replacement. Combining treatment effects, there was a significant reduction in body weight and HbA1c at 3‐months post‐therapy switch. Replacement with MR‐HC in adults with AI is associated with significant improvements in anthropometric measurements and HbA1c compared with SG replacement, especially those with DM.