MacDonald ML, Garver M, Newman J, et al. - In this paired case-control study, researchers ascertained if the protein levels of people with schizophrenia were altered within synapses from the primary auditory cortex (A1) and, if so, whether these changes are limited to synapse or exist throughout the gray matter. For this investigation, they examined synaptosome and homogenate protein levels in 48 people with a schizophrenia diagnosis and 48 controls (mean age in both groups, 48 years [range, 17-83 years]). According to results, robust alterations were found in highly coregulated synaptic levels of mitochondrial and postsynaptic proteins, including glutamate and γ-aminobutyric acid receptors, not related to underlying differences in total gray matter levels. Such results indicate a broad and highly coordinated schizophrenic rearrangement of the synaptic proteome that is best explained by changes in local synaptic, but not tissue-wide, protein homeostasis.