Seravalle G, et al. – Experts in this study illustrated sympathetic nerve traffic and blood pressure changes after bilateral renal denervation in resistant hypertension. A close link between the sympathetic activity and BP responses to this procedure was reported by time–integrated changes in corrected muscle sympathetic nerve activity (MSNA) (MSNAC) and blood pressure (BP) after bilateral renal denervation. The relevance of the sympathetic nervous system both in the pathophysiology of resistant hypertension and in the BP–lowering effect of the procedure was strengthened.