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Sustained remission of granulomatosis with polyangiitis after discontinuation of glucocorticoids and immunosuppressant therapy: Data from the French vasculitis study group registry

Arthritis & Rheumatology Mar 12, 2021

Puéchal X, Iudici M, Pagnoux C, et al. - This study was sought to explore sustained remission off‐therapy (SROT) among granulomatosis with polyangiitis (GPA) patients from the French Vasculitis Study Group Registry to distinguish factors associated with its occurrence and durability. Researchers compared 92 GPA patients with SROT at 3 years postdiagnosis with 342 control individuals who had experienced disease relapse and/or were still receiving glucocorticoids (GCs) or immunosuppressants among 795 patients with GPA. At 10 years postdiagnosis, 7% of GPA patients had reached SROT after conventional therapies. It was shown that no baseline vasculitis characteristics distinguished individuals who achieved/maintained SROT from those who experienced disease relapse and/or those who continued to receive GCs or immunosuppressant therapy, but patients with SROT had received more intensive induction therapy and rituximab as maintenance therapy more frequently.

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