Xie W, et al. - Medical records of rheumatoid arthritis (RA) subjects from 2009 to 2016 were retrospectively evaluated by experts in order to examine the prevalence and predictors of sustained remission (SR) in an unselected Chinese RA population. Seven hundred and seventy-nine subjects contributing to 7,958 clinic visits were recruited in the study. About half of the cases accomplished a 6-month SR according to Disease Activity Score in 28 joints using erythrocyte sedimentation rate, Clinical Disease Activity Index, Simplified Disease Activity Index, as well as Boolean definitions, during the follow-up period. Median time periods to 6-month SR were 20.5, 28.7, 30.6, and 32.9 months, respectively. Depending on instruments, 29.4% to 41.2% of patients attained a 6-month SR at least once in the first year of follow-up. Progressing age, more prolonged disease span, raised baseline disease activity were independently associated with a decreased possibility of 6-month SR assessed by nearly all definitions. Conversely, male, early RA, disease-modifying antirheumatic drug-naïve and lower disease activity scores in remission estimated by corresponding criteria positively added to SR. Stable determinants of SR across all definitions were treat-to-target (T2T) adherence therapy and shorter time to remission. Hence, attaining a 6-month SR was not unusual in daily practice. Furthermore, male, early RA, treatment-naïve, T2T application, shorter course to remission, and lower disease activity scores in remission elevated the occurrence of SR, while progressing age, longer disease term, and greater baseline disease activity decreased the chance of remission sustainability.