Hassan AN, Le Foll B, et al. - This research sought to calculate the survival probabilities related to the occurrence of major depressive episodes (MDEs) after the onset of substance use disorders (SUDs) using data from the 2012–2013 National Epidemiologic Survey on Alcohol and Related Conditions-III. Researchers used Alcohol Use Disorder and Associated Disabilities Interview Schedule-5 to diagnose SUD, and psychiatric diagnoses were based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. The data demonstrate that users of all studied substances have an elevated probability of having an MDE over the lifespan.