Lewis DR, Siembida EJ, Seibel NL, et al. - Researchers studied long-term survival trends for cancer types with the highest mortality among adolescent and young adults (AYA) to ascertain where the greatest burden is and to determine areas for future exploration. Data were extracted from the Surveillance, Epidemiology, and End Results cancer registry and the National Center for Health Statistics. Experts analyzed incidence, mortality, and survival for the 9 cancer types with the highest death rates in this age group from 1975 to 2016. Findings revealed that improvement has been noted in 5-year relative survival for multiple cancer types in AYAs, however, some common malignancy types in this group still exhibited limited survival improvements (eg, ovarian cancer). The increasing incidence of colorectal cancer has overshadowed survival improvements in this cancer type, indicating a substantial disease burden. Minimal or no improvements in survival were shown by female breast, bone, ovarian, and cervical cancers, and thus, these represent areas for future research.