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Survival of patients with chronic heart failure in the community: A systematic review and meta-analysis

European Journal of Heart Failure Sep 25, 2019

Jones NR, et al. - Researchers analyzed 60 non-interventional studies with 1.5 million patients, to offer reliable survival estimates for individuals with chronic heart failure and to describe the difference in survival by key factors including age at diagnosis, left ventricular ejection fraction, decade of diagnosis, and study setting. The included studies were identified from relevant databases and informed survival rates for patients with chronic or stable heart failure in any ambulatory setting. At 1 month, 1, 2, 5 and 10 years, the pooled survival rates were 95.7%, 86.5%, 72.6%, 56.7% and 34.9%, respectively, in random effects meta-analyses. They found a significant association between increasing age at diagnosis and a decrease in survival time. Investigations performed in secondary care revealed the lowest mortality, with higher reported prescribing rates of key heart failure medications. This study offers information relevant to health policy and individual patient advanced care planning. Though steady improvements in survival were reported, mortality related to chronic heart failure continued to be high. Via greater implementation of evidence-based treatments, there is a significant scope to improve prognosis.
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