Brudvik KW, et al. - The current study explored survival after resection of colorectal liver metastases (CLM) in octogenarians compared to sexagenarians and their respective age-matched national population. Researchers reported that the survival was poorer in octogenarians than in sexagenarians after resection of CLM. It was noted that the difference between the survival curves of patients and their age-matched population was smaller in octogenarians. The results obtained from the study might indicate a greater benefit of resection in the elderly than suggested by survival rates alone.

Methods

• Octogenarian and sexagenarian were individuals 80–89 and 60–69 years of age, respectively.
• Researchers performed survival analyses of patients who had resection of CLM between 2002 and 2014.
• Using data from Statistics Norway, they assessed the survival of the age-matched national population of octogenarians (ageM-Octo) and the age-matched national population of sexagenarians (ageM-Sexa).

Results

• Fifty-nine octogenarians had resection of CLM during the study period.
• It was observed that the majority of patients had a minor liver resection (n=50).
• The 5-year survival in octogenarians was 32.5% and 66.3% (difference, 33.8 percentage points [pp]) in patients and ageM-Octo, respectively; the 10-year survival was 14.1% and 31.2% (difference, 17.1 pp) in patients and ageM-Octo, respectively.
• The 5-year survival in sexagenarians was 50.9% and 96.2% (difference, 45.3 pp) in patients and ageM-Sexa, respectively; the 10-year survival was 35.7% and 90.3% (difference, 54.6 pp) in patients and ageM-Sexa, respectively.
• They found that the 5-year cancer-specific survival and 5-year recurrence-free survival (RFS) after resection of CLM in octogenarians were 43.1% and 32.9%, respectively.