Goldman ML, Mao JJ, Strouse CS, et al. - Among patients suffering from follicular lymphoma (FL), how surveillance imaging could impact relapse detection as well as overall survival (OS) was investigated retrospectively in this study. Participants were patients with newly diagnosed FL who had a response to induction therapy. These patients were selected from the Lymphoid Malignancies Enterprise Architecture Database (LEAD) at Emory University and from the Molecular Epidemiology Resource (MER) of the University of Iowa/Mayo Clinic. Participants were assessed for relapse as well as for method of relapse identification (ie, clinical concerns vs radiologic detection through surveillance imaging in an asymptomatic patient). Relapse occurred in 55 (37%) of 148 patients in the LEAD cohort, and most of the relapses (n = 35; 64%) were detected clinically. Clinical detection of 63 of 177 relapses (54%) in the MER cohort was reported. OS from the date of diagnosis did not differ significantly between the 2 methods of relapse detection in the LEAD and MER cohorts. Findings indicate that routine surveillance imaging has a limited role in FL patients who complete front-line therapy.