Frisina R, et al. - For the treatment of refractory full-thickness macular hole, researchers tested the safety and effectiveness of surgically induced macular detachment. For this investigation, 10 eyes of 10 patients (mean age was 68.8 ± 6.8 years) have been involved. A negative correlation was demonstrated between intersurgical interval and postoperative visual gain. Optical coherence tomography and fundus autofluorescence displayed a permanent retinal pigment epithelium (RPE) damage corresponding to the retinotomy points. This research shows the effectiveness of this method and highlights the danger of RPE harm, indicating that retinotomy points need to be performed outside the macula.