Zamborsky R, et al. - Researchers sought to examine the most appropriate surgical interventions for individuals with knee articular cartilage defects from the level I randomized clinical trials. Twenty-one articles were studied that involved 891 individuals. The most common cause in the included patients was a traumatic lesion. Cartilage repair techniques have higher quality tissue repair and have lower failure and higher return-to-activity rates, rather than MF. In addition, osteochondral autograft transplantation had significantly more excellent or good results vs microfracture (MF), while MF had significantly poorer results compared with autologous chondrocyte implantation and matrix-induced autologous chondrocyte implantation. To examine the efficacy and safety of these interventions, future studies need to have longer follow-up periods and more representative populations.