Vuong KT, et al. - Authors evaluated the published data on the development of biopsy-site primary cutaneous melanoma among biopsy-proven histologically dysplastic naevi (HDN) managed with either re-excision or observation. In this systematic review of all published data, a total of 5293 records were screened, 18 articles were assessed in full text and 12 studies met inclusion criteria. They noted similarly low rates of biopsy-site primary melanoma among observed lesions and re-excised lesions. There was a probability of HDNs to be observed with minimal adverse melanoma-associated outcomes.