Qu R, Tu D, Ping W, et al. - Researchers retrospectively reviewed clinical characteristics and treatment outcomes of patients with ≥ 3 lesions who have been diagnosed as synchronous multiple primary lung adenocarcinomas (SMPLA) and underwent surgical resection.

• Included were 28 patients with ≥ 3 lesions who have been diagnosed as SMPLA and underwent surgical resection.

• Among a total of 95 lesions, 86.4% were ground-glass opacity (GGO) lesions (pure-GGO,45.3%; mixed-GGO,41.1%); EGFR mutations were detected in 51 lesions and significantly higher mutation rate was recorded in invasive adenocarcinoma vs other pathological subtypes; also, significantly higher mutation rate of mGGO was recorded when compared with that of pGGO and solid nodule (SN).

• One-stage resection may be safe and feasible for managing the cases with SMPLA with ≥ 3 lesions.

• In studied cases, mainly sublobar resection, as far as possible, was performed, which can yield satisfactory prognosis.

• Routine use of EGFR mutation testing is recommended in the diagnosis and treatment of patients with SMPLA, especially in the presence of mGGO and invasive adenocarcinoma.