Huang G, et al. - In this prospective cohort study involving older postmenopausal women conducted across four US clinical centers with up to 18 years of follow-up, researchers compared the risk of frailty in women with surgical menopause vs naturally menopausal women. They examined community-dwelling white women aged ≥ 65 years (mean age, 71.2 ± 5.2 years) enrolled in the Study of Osteoporotic Fractures (N=7,699). Surgical menopause was participant-reported and defined as bilateral oophorectomy prior to menopause. A total of 12.6% of participants reported surgical menopause at baseline. Of these participants, 22.0% died, and 10.1% were classified as frail, 39.7% were classified as prefrail, and 28.3% were classified as robust. Overall, the investigators did not observe any association of surgical menopause with greater risk for frailty vs naturally menopausal women in this study population, even in the absence of estrogen therapy.