Surgical delays of less than 1 year in Mohs surgery associated with tumor growth in moderately- and poorly-differentiated squamous cell carcinomas but not lower-grade squamous cell carcinomas or basal cell carcinomas: A retrospective analysis
Journal of the American Academy of Dermatology Oct 12, 2021
Lee J, Forrester VJ, Novicoff WM, et al. - For higher-grade squamous cell carcinomas (SCCs), an association between surgical delays of less than a year and tumor growth was found, with effect sizes holding potential for clinical significance.
This is a retrospective study of 299 SCCs and 802 basal cell carcinomas managed with Mohs surgery at a single institution.
Surgical delays ranged from 0 to 331 days, and independent predictors of change in major diameter (ΔMD: from size at biopsy to postoperative defect) in SCCs were: histologic subtype and prior treatment.
There were significant links between ΔMD and surgical delay for poorly- and moderately-differentiated SCCs, showing growth rates of 0.28 cm and 0.24 cm per month of delay, respectively.
For SCCs with prior treatment and basal cell carcinoma subgroups, ΔMD did not vary with surgical delay.
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