Zhu MF, Kim K, Cavadino A, et al. - The present study was attempted to ascertain the success of debridement, antibiotics, and implant retention (DAIR) in a large cohort of total knee arthroplasty (TKA) prosthetic joint infections (PJIs) and evaluate the usefulness of current classification systems in predicting DAIR outcomes in early postoperative, late hematogenous, and chronic PJIs. Researchers conducted a multicenter review over 15 years including a total of 230 patients who had undergone DAIR for first episode PJI following primary TKA. Factors associated with successful DAIR were identified by performing univariate and multivariate survival analyses. The outcomes suggested that DAIR has a high failure rate in all PJIs occurring more than a year post-primary TKA, especially when caused by S aureus or gram-negative bacteria. The data revealed that age of the implant is an important prognosticator of DAIR outcomes.