Stander S, et al. - The pathogenesis of chronic pruritus, centering the role of substance P (SP) and neurokinin 1 receptor (NK₁R) in itch signaling was estimated to illustrate NK₁R antagonism as a likely approach for the treatment of chronic pruritus. Investigators observed NK₁R expression in the central nervous system and on multiple cell types, involved in the initiation and transmission of itch. Disruption of NK₁R antagonism in itch signaling reduced the itch and acted as a potential treatment of chronic pruritus across multiple diseases. It was also noted that SP and NK₁R were overexpressed across multiple chronic itch-inducing conditions.