Jakobiec FA, Barrantes PC, Yonekawa Y, et al. - Researchers conducted this retrospective case series to assess the mononuclear cells in the subretinal exudate in Coats’ disease. In order to identify the intraretinal and subretinal exudative cells, five enucleated globes and one cytology sample with Coats’ disease and one case of chronic retinal detachment following repair of an open globe injury have been studied immunohistochemically. There are several well-delineated phenotypes and functions in the retinal pigment epithelium. The pigment epithelium supports the photoreceptors in normal visual physiology and participates in their renewal through y phagocytosis of the tips of the photoreceptors. Together with RPE65 in the retinal pigment epithelium, the expression of CD163, a characteristic of hematopoietically derived monocytes, supports the differentiation towards histiocytes. Yellow staining detached pigment epithelial cells were unusual. The existence of histiocytoid pigment epithelium at the level of Bruch’s membrane possibly also has consequences for macular degeneration.