Strejilevich SA, Camino S, Caravotta P, et al. – Experts reviewed published data of subjective response to antipsychotic (SRA)— defined as changes in the subjective state experienced due to antipsychotic (AP) exposition that is independent of the therapeutic or physical side effects of these drugs—in patients with bipolar disorder (AD), and discussed the clinical and theoretical implications of their findings. They evaluated nine reports including data from 1,282 patients with BD, and found asymmetry between the increase in the use of antipsychotics in BD and the lack of data regarding the SRA. Phenomenologically, SRA in BD was found to be similar to that found in people with schizophrenia. Furthermore, some of these symptoms may be misdiagnosed as depressive symptoms. According to existing data, SRA is strongly correlated with treatment compliance as well as a promising strategy to develop theoretical paradigms for these disorders.