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Subjective cognitive complaints in early Parkinson disease patients with normal cognition are associated with affective symptoms

Parkinsonism & Related Disorders Nov 22, 2020

Chua CY, Rui En Koh M, Shuang-Yu Chia N, et al. - Given that in Parkinson disease (PD), there is a high prevalence of subjective cognitive complaints (SCC) and affective symptoms, researchers used recommended Movement Disorders Society Level II Criteria to define the underlying cognitive impairment in early PD and how it relates to SCC. Researchers analyzed 121 participants with early PD. Independent of underlying cognitive status, SCC prevalence in the early PD cohort was estimated to be 38.8%. Among cognitively normal PD patients, a significant link of SCC with anxiety, depression and apathy was revealed in multivariable linear regression analysis. Overall, findings showed a high prevalence of SCC, even in early PD. Based on underlying cognitive status, its implications in early PD varied. Experts noted that SCC in cognitively impaired individuals underestimated the true prevalence of PD-MCI (Mild Cognitive Impairment), whereas, an underlying affective disorder was suggested by SCC in cognitively normal participants.

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