Chan NK, Gerretsen P, Chakravarty MM, et al. - As an increase in apathy prevalence has been observed with severity of dementia pathology, researchers wanted to discriminate concomitant neurodegenerative processes from brain disparities linked with apathy in persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD). Cognitively impaired patients with and without apathy were assessed for relative structural brain differences. In this cross-sectional case-control study, participants with apathy (n = 69) were age-, gender-, apolipoprotein E ε4 allele carrier status-, Mini-Mental State Exam score-, and MCI or AD dementia diagnosis-matched to participants without apathy (n = 149). Performing the 3-tesla T1-weighted MRI scan and neurocognitive assessments, they identified that apathetic cognitively impaired participants had thinner right medial orbitofrontal (mOFC) and left rostral anterior cingulate (rACC) cortices and thicker left middle temporal cortex (MTC) relative to non-apathetic cognitively impaired participants. This suggests a specific association of apathy with thinner right mOFC and left rACC and thicker left MTC.