Fife D, Blacketer C, Knight RK, et al. - Among patients aged ≥ 65 years, regardless of dementia status, researchers assessed stroke risk as it correlated with new exposure to haloperidol or any typical antipsychotic vs atypical antipsychotics. They used data from IBM MarketScan Medicare Supplemental Database (January 1, 2001 to December 31, 2017) for this study. The risk of stroke for new typical antipsychotics (T1 cohort) or haloperidol (T2 cohort) users was contrasted with new atypical antipsychotics (C1 cohort) users aged ≥ 65 years. Unadjusted (crude), Sentinel PS replication, and a large-scale regularized regression model (adapted PS) were the three propensity score matching strategies were used. Overall, 36,734 (T1), 24,074 (T2), and 226,990 (C1) patients were assessed. The risk of stroke in elderly new haloperidol users was higher vs new users of atypical antipsychotics, as it also was for users of typical antipsychotics, utilizing the adapted PS strategy.